ODCs

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1 OMIM reference -
1 associated gene
8 signs/symptoms

PROTEIN INTERACTIONS: 1
COMMON SIGNS: 3

1 OMIM reference -
4 associated genes
8 signs/symptoms

Superficial epidermolytic ichthyosis

Epidermolytic palmoplantar keratoderma


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	KRT2	(0.49)	KRT1

Citations in the biomedical literature:

Superficial epidermolytic ichthyosis		Epidermolytic palmoplantar keratoderma
	Synonym(s): - Ichthyosis bullosa of Siemens - SEI		Synonym(s): - Diffuse erythrodermic palmoplantar keratoderma, Voerner type - Diffuse erythrodermic palmoplantar keratoderma, VÃ¶rner type - EPPK - Epidermolytic palmoplantar keratoderma of Voerner - Epidermolytic palmoplantar keratoderma of VÃ¶rner

	Classification (Orphanet): - Rare genetic disease - Rare skin disease		Classification (Orphanet): - Rare genetic disease - Rare skin disease

	Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: neonatal/infancy Average age of death: no data available Type of inheritance: autosomal dominant		Epidemiological data: (no data available)

	External references: 1 OMIM reference - 1 MeSH reference: D053560		External references: 1 OMIM reference - No MeSH references


COMMON SIGNS	- Autosomal dominant inheritance - Erythema / erythematous lesions / erythroderma / polymorphous erythema - Palmoplantar hyperkeratosis / keratoderma

Superficial epidermolytic ichthyosis		Epidermolytic palmoplantar keratoderma
	Very frequent - Cutaneous edema - Ichthyosis / ichthyosiform dermatitis - Positive Nikolski's sign / achantolysis - Thin skin - Vesicles / bullous / exsudative lesions / bullous / cutaneous / mucosal detachment		Very frequent - Hyperkeratosis / ainhum / hyperkeratotic skin fissures - Warts / papillomas Frequent - Abnormal fingernails - Eczema - Hyperhidrosis / increased sweating